Gestión de los procesos operativos y la toma de decisiones en empresas de servicios

La gestión dentro de las empresas representa una gran herramienta tanto para el control, así como el desarrollo de sus actividades, debido a que dentro de ellas se llevan a cabo procesos cada vez más estructurados, acompañados de niveles cada vez más complejos; por lo tanto, se requiere una adecuada toma de decisiones, con el fin de administrar y usar adecuadamente recursos, información y tiempo, con miras de impactar de manera positiva en los clientes, acompañándolo del cumplimiento de objetivos. En el caso de las empresas que conforman el sector de servicios, se cuenta con un control empírico o rudimentario, aplicado por sus propietarios basándose en experiencias connegocios de similares características, lo cual no lo hace eficiente, debido a que la información que proporcionan los procesos no es relevante puesto que no refleja la situación real de las empresas, repercutiendo en la toma de decisiones. Tomando en consideración lo antes mencionado y basado sobre la revisión literaria, realizada en base de datos como Scielo, Dialnet, entre otros; se ha desarrollado el presente artículo con el objetivo de dar a conocer la importancia de la gestión, en este caso de los procesos operativos en la toma de decisiones en las empresas de servicios

iTETRIS: An Integrated Wireless and Traffic Platform for Real-Time Road Traffic Management Solutions

Wireless vehicular cooperative systems have been identified as an attractive solution to improve road traffic management, thereby contributing to the European goal of safer, cleaner, and more efficient and sustainable traffic solutions. V2V-V2I communication technologies can improve traffic management through real-time exchange of data among vehicles and with road infrastructure. It is also of great importance to investigate the adequate combination of V2V and V2I technologies to ensure the continuous and costefficient operation of traffic management solutions based on wireless vehicular cooperative solutions. However, to adequately design and optimize these communication protocols and analyze the potential of wireless vehicular cooperative systems to improve road traffic management, adequate testbeds and field operational tests need to be conducted. Despite the potential of Field Operational Tests to get the first insights into the benefits and problems faced in the development of wireless vehicular cooperative systems, there is yet the need to evaluate in the long term and large dimension the true potential benefits of wireless vehicular cooperative systems to improve traffic efficiency. To this aim, iTETRIS is devoted to the development of advanced tools coupling traffic and wireless communication simulators

Investigating the Efficiency of ITS Cooperative Systems for a Better Use of Urban Transport Infrastructures: The iTETRIS Simulation Platform

The use of cooperative ITS communication systems, supporting driving through the dynamic exchange of Vehicle-to- Vehicle (V2V) and Vehicle-to-Infrastructure (V2I) messages, is a potential candidate to improve the economical and societal welfare. The application of such systems for novel cooperative traffic management strategies can introduce a lot of beneficial effects not only for road safety, but also for the economy related to transportation systems and the environmental impact. Despite this apparent set of promising features, City Road Authorities, which hold a key-role in determining the final adoption of such systems, still look at cooperative systems without sharing a clear opinion. This is mainly due to the current lack of definitive and solid evidences of the effectiveness of such systems when applied in the real world. In order to fill this gap and let Road Authorities estimate the usefulness of such technologies in achieving the objectives dictated by cities’ traffic management policies, the EU consortium iTETRIS is developing a simulation platform for large scale testing of traffic management solutions making use of cooperative ITS systems. Thanks to its own distinguishing features, iTETRIS aims at becoming a good supporting tool for Road Authorities to implement preliminary tests on the effectiveness of ITS solutions prior to investing money for the physical deployment of the communication infrastructures allowing their functioning

Consideraciones actuales de la inyección percutánea de etanol en el bocio nodular benigno

Introducción: La inyección percutánea de etanol se ha utilizado en el tratamiento de carcinomas hepatocelulares pequeños, lesiones hepáticas metastásicas, adenomas paratiroideos primarios o secundarios y, de forma esporádica, en otras neoplasias endocrinas benignas como los adenomas adrenocorticales productores de aldosterona. Objetivos: Actualizar en el conocimiento del empleo y los resultados de la inyección percutánea de etanol para el tratamiento de los pacientes con bocio nodular. Desarrollo: La evidencia actual respalda el uso de la inyección percutánea de etanol como tratamiento de primera línea para quistes puros y nódulos tiroideos predominantemente quísticos. Reduce de forma significativa el volumen y el diámetro mayor tanto en nódulos sólidos como quísticos. En un nódulo quístico, puede lograr una reducción del volumen de 85 a 95 %. Sin embargo, en un nódulo predominantemente quístico, la tasa de reducción de volumen varía del 60 % al 90 %. Los resultados para nódulos predominantemente quísticos con una porción sólida menor al 20 % son satisfactorios. En nódulos tiroideos sólidos, se reportan tasas de éxito de 75 a 86,6 %, considerando los pacientes que refieren mejoría estética post tratamiento. Conclusiones: La inyección percutánea de etanol se emplea como método de tratamiento seguro y eficaz para pacientes con bocio nodular benigno. Puede brindarse como alternativa terapéutica en países donde la cirugía y la observación clínica son las principales opciones de tratamiento para estos pacientes

Current considerations on treatment options for patients with benign nontoxic multinodular goiter

Introduction: Benign nontoxic multinodular goiter is one of the most common endocrine diseases and there is no consensus on the ideal treatment. The options should be evaluated individually, for each patient, taking into account factors such as risk-benefit ratio, patient preference and experience of the treating physician. Objective: To update the knowledge of therapeutic options for patients with benign nontoxic multinodular goiter. Development: The current alternatives for treatment are: clinical follow-up for asymptomatic patients; suppressive therapy with levothyroxine; therapy with radioactive iodine alone or preceded by recombinant human TSH and surgical intervention. Other authors include within these alternatives, minimally invasive techniques. Conclusions: Surgical intervention is the fundamental option for the treatment of the symptomatic patient. Minimally invasive procedures show good results in improving quality of life and patient satisfaction. More long-term follow-up studies of these patients are required

Facile solventless synthesis of a nylon-6,6/silver nanoparticles composite and its XPS study

SINTESIS DE NANOPARTICULASSilver nanoparticles were synthesized and supported on thin nylon membranes by means of a simple method of impregnation and chemical reduction of Ag ions at ambient conditions. Particles of less than 10nm were obtained using this methodology, in which the nylon fibers behave as constrained nanoreactors. Pores on nylon fibres along with oxygen and nitrogen from amide moieties in nylon provide effective sites for in situ reduction of silver ions and for the formation and stabilization of Ag nanoparticles. Transmission electron microscopy (TEM) analysis showed that silver nanoparticles are well dispersed throughout the nylon fibers. Furthermore, an interaction betweenUAEME

ATR is required to complete meiotic recombination in mice

Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). Cellular responses to meiotic DSBs are critical for efficient repair and quality control, but molecular features of these remain poorly understood, particularly in mammals. Here we report that the DNA damage response protein kinase ATR is crucial for meiotic recombination and completion of meiotic prophase in mice. Using a hypomorphic Atr mutation and pharmacological inhibition of ATR in vivo and in cultured spermatocytes, we show that ATR, through its effector kinase CHK1, promotes efficient RAD51 and DMC1 assembly at RPA-coated resected DSB sites and establishment of interhomolog connections during meiosis. Furthermore, our findings suggest that ATR promotes local accumulation of recombination markers on unsynapsed axes during meiotic prophase to favor homologous chromosome synapsis. These data reveal that ATR plays multiple roles in mammalian meiotic recombination.We thank M. A. Handel (The Jackson Laboratory, Bar Harbor, USA) for the anti-H1T antibody; E. Marcon for the anti-RPA antibody (University of Toronto, Canada); A. Toth for the anti-pHORMAD2 antibody (U. Dresden, Germany) and N. Hunter for the anti- RNF212 antibody (UC Davis, USA); J. Turner (National Institute for Medical Research,London, UK) for assistance in the RNA-FISH experiments, for the X chromosome probe,for providing AtrFL/−testis samples and for sharing unpublished data; L. Kauppi(University of Helsinki, Finland) for providing us with protocols for the testis cultures;and members of the Roig lab and the Spanish Ministerio de Ciencia e Innovación-funded Network of Spanish groups working on Meiosis (MeioNet, BFU201‐71786‐REDT) and Enrique Martínez Pérez (Imperial College, London, UK) for helpful discussions. M.M.O. was supported by a FPI fellowship from the Ministerio de Ciencia e Innovación (BES-2011-045381). J.L. was supported in part by American Cancer Society post-doctoral fellowship (PF-12-157-01-DMC). S.K. is an Investigator of the Howard Hughes Medical Institute. This work was supported by the Ministerio de Ciencia e Innovación (BFU2010-18965, BFU2013-43965-P and BFU2016-80370-P, I.R.), by the UAB-Aposta award to young investigators (APOSTA2011-03, I.R.) and by the NIH (R35 GM118175, to M.J.and R35 GM118092 to S.K.).S

Transfection of bovine fetal fibroblast with polyethylenimine (PEI) nanoparticles: effect of particle size and presence of fetal bovine serum on transgene delivery and cytotoxicity

The development of efficient transfection protocols for livestock cells is crucial for implementation of cell-based transgenic methods to produce genetically modified animals. We synthetized fully deacylated linear 22, 87 and 217 kDa polyethylenimine (PEI) nanoparticles and compared their transfection efficiency and cytotoxicity to commercial branched 25 kDa PEI and linear 58 kDa poly(allylamine) hydrochloride. We studied the effect of PEI size and presence of serum on transfection efficiency on primary cultures of bovine fetal fibroblasts and established cells lines (HEK 293 and Hep G2). We found that transfection efficiency was affected mainly by polymer/pDNA ratio and DNA concentration and in less extent by PEI MW. In bovine fibroblast, preincubation of PEI nanoparticles with fetal bovine serum (FBS) greatly increased percentage of cells expressing the transgene (up to 82%) while significantly decreased the polymer cytotoxic effect. 87 and 217 kDa PEI rendered the highest transfection rates in HEK 293 and Hep G2 cell lines (>50% transfected cells) with minimal cell toxicity. In conclusion, our results indicate that fully deacylated PEI of 87 and 217 kDa are useful DNA vehicles for non-viral transfection of primary cultures of bovine fetal fibroblast and HEK 293 and Hep G2 cell lines.Fil: Forcato, Diego Oscar. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Fili, Alejandro. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Alustiza, Fabrisio Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Bongiovanni Abel, Silvestre Manuel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Olmos Nicotra, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Alessio, Ana Paula. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Rodriguez, Natalia Evelin. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Barbero, César Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Bosch, Pablo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentin

Circulating linoleic acid at the time of myocardial infarction and risk of primary ventricular fibrillation

Primary ventricular fibrillation (PVF) is a major driver of cardiac arrest in the acute phase of ST-segment elevation myocardial infarction (STEMI). Enrichment of cardiomyocyte plasma membranes with dietary polyunsaturated fatty acids (PUFA) reduces vulnerability to PVF experimentally, but clinical data are scarce. PUFA status in serum phospholipids is a valid surrogate biomarker of PUFA status in cardiomyocytes within a wide range of dietary PUFA. In this nested case-control study (n = 58 cases of STEMI-driven PVF, n = 116 control non-PVF STEMI patients matched for age, sex, smoking status, dyslipidemia, diabetes mellitus and hypertension) we determined fatty acids in serum phospholipids by gas-chromatography, and assessed differences between cases and controls, applying the Benjamini-Hochberg procedure on nominal P-values to control the false discovery rate (FDR). Significant differences between cases and controls were restricted to linoleic acid (LA), with PVF patients showing a lower level (nominal P = 0.002; FDR-corrected P = 0.027). In a conditional logistic regression model, each one standard deviation increase in the proportion of LA was related to a 42% lower prevalence of PVF (odds ratio = 0.58; 95% confidence interval, 0.37, 0.90; P = 0.02). The association lasted after the inclusion of confounders. Thus, regular consumption of LA-rich foods (nuts, oils from seeds) may protect against ischemia-driven malignant arrhythmias

Investigating the Efficiency of ITS Cooperative Systems for a Better Use of Urban Transport Infrastructures: The iTETRIS Simulation Platform

The use of cooperative ITS communication systems, supporting driving through the dynamic exchange of Vehicle-to- Vehicle (V2V) and Vehicle-to-Infrastructure (V2I) messages, is a potential candidate to improve the economical and societal welfare. The application of such systems for novel cooperative traffic management strategies can introduce a lot of beneficial effects not only for road safety, but also for the economy related to transportation systems and the environmental impact. Despite this apparent set of promising features, City Road Authorities, which hold a key-role in determining the final adoption of such systems, still look at cooperative systems without sharing a clear opinion. This is mainly due to the current lack of definitive and solid evidences of the effectiveness of such systems when applied in the real world. In order to fill this gap and let Road Authorities estimate the usefulness of such technologies in achieving the objectives dictated by cities’ traffic management policies, the EU consortium iTETRIS is developing a simulation platform for large scale testing of traffic management solutions making use of cooperative ITS systems. Thanks to its own distinguishing features, iTETRIS aims at becoming a good supporting tool for Road Authorities to implement preliminary tests on the effectiveness of ITS solutions prior to investing money for the physical deployment of the communication infrastructures allowing their functioning